Progenesis is a rare item in Path of Exile designed to modify the player's life loss mechanic. It distributes 25% of life loss from damage over 4 seconds when hit, rather than occurring instantly. This feature helps players manage large amounts of incoming damage more effectively, reducing the risk of sudden character defeat.
The life loss is distributed over time, which gives players a better chance to react and use healing or defensive strategies.
The flask lasts between 2.92 to 6.07 seconds in Ruthless mode and requires 28 to 31 of 65 charges per use. This variability allows players to adapt the flask's usage to different combat scenarios. Additionally, its unique effect synergizes well with other game mechanics.
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